Locate the box at the bottom of the General tab.

Shadow rendering requires massive CPU and GPU coordination. Disabling this provides the single largest FPS jump in the graphics menu. High

If your game still struggles after lowering the built-in settings, the standard options menu lacks the precision tools you need. The single most effective community workaround for low-end systems is utilizing a available via the Steam Workshop.

You will run out of CPU power long before you run out of GPU power in this game. Therefore, our settings will prioritize reducing CPU load first, then VRAM (video memory), then GPU processing.

To stabilize your frame rate, you must disable visual effects that require heavy compute pipelines. Use this targeted profile within the in-game options menu to instantly decrease the rendering load on your system. Why Cities: Skylines 2 performs poorly - paavohtl's blog

Many workshop creators upload unoptimized 3D models with massive texture files (e.g., 4K textures for a simple house). Avoid these at all costs.

Medium. (Setting this to Low makes text unreadable; Medium is usually a safe bet for 2GB VRAM).