Even with the right cable, the software won't "talk" to the radio unless the COM port settings match. Plug in your cable and open on your PC.
The software is just a tool; the workflow is the skill. Now you know how to make the Vertex VX351 programming software work for you.
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Modify your channels, CTCSS/DCS tones, and power settings in the spreadsheet interface.
Connect the radio to the PC using the FIF-12 and CT-106. Turn the radio OFF . In the CE86 software, click the Read button (or press F5). When prompted, turn the radio ON . vertex vx351 programming software work
The most common reason the software "won't work" is a driver mismatch. Prolific/FTDI Drivers
When prompted by the screen, to begin the data transfer. Even with the right cable, the software won't
Making Vertex VX351 Programming Software Work: A Complete Guide