If your Q49 is not performing as expected, try these solutions:

Sometimes Windows incorrectly assigns a MIDI device. You can reset it easily:

Switch to a different USB port or replace the USB cable entirely. Faulty cables are the most common cause of MIDI dropout.

The Alesis Q49 draws power via USB. Modern computers (post-2021) utilize USB 3.0 and USB-C ports which may negotiate power differently than older USB 2.0 ports.

If the lights on your keyboard do not turn on, your USB port may not be supplying enough power. Try using a 9V DC 500mA power adapter (sold separately) alongside the USB connection. Fix Windows Device Manager Conflicts

Adjust the buffer size to to achieve near-zero latency. For macOS Users: CoreAudio